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CXCL13 predicts disease activity in early rheumatoid arthritis and could be an indicator of the therapeutic 'window of opportunity'.

Identifieur interne : 000419 ( Main/Exploration ); précédent : 000418; suivant : 000420

CXCL13 predicts disease activity in early rheumatoid arthritis and could be an indicator of the therapeutic 'window of opportunity'.

Auteurs : Stinne Ravn Greisen ; Karen Kr Mmer Schelde ; Tue Kruse Rasmussen ; Tue Wenzel Kragstrup ; Kristian Stengaard-Pedersen ; Merete Lund Hetland ; Kim H Rslev-Petersen ; Peter Junker ; Mikkel Stergaard ; Bent Deleuran ; Malene Hvid

Source :

Arthritis research & therapy ; 2014.

RBID : pubmed:25249397

English descriptors

KwdEn :
- Adalimumab, Antibodies, Monoclonal, Humanized (therapeutic use), Antirheumatic Agents (therapeutic use), Arthritis, Rheumatoid (blood), Arthritis, Rheumatoid (diagnosis), Arthritis, Rheumatoid (drug therapy), Chemokine CXCL13 (blood), Drug Therapy, Combination, Early Diagnosis, Female, Humans, Joints (drug effects), Joints (metabolism), Joints (pathology), Male, Methotrexate (therapeutic use), Middle Aged, Predictive Value of Tests, Prognosis, Remission Induction, Severity of Illness Index, Time Factors, Treatment Outcome.
MESH :
- chemical , blood : Chemokine CXCL13.
- chemical , therapeutic use : Antibodies, Monoclonal, Humanized, Antirheumatic Agents, Methotrexate.
- chemical : Adalimumab.
- blood : Arthritis, Rheumatoid.
- diagnosis : Arthritis, Rheumatoid.
- drug effects : Joints.
- drug therapy : Arthritis, Rheumatoid.
- metabolism : Joints.
- pathology : Joints.
- Drug Therapy, Combination, Early Diagnosis, Female, Humans, Male, Middle Aged, Predictive Value of Tests, Prognosis, Remission Induction, Severity of Illness Index, Time Factors, Treatment Outcome.

Abstract

A key phenomenon in rheumatoid arthritis is the formation of lymphoid follicles in the inflamed synovial membrane. C-X-C motif chemokine 13 (CXCL13) is central in this process as it attracts C-X-C chemokine receptor type 5 (CXCR5)-expressing B cells and T follicular helper cells to the follicle. We here examine the role of CXCL13 and its association with disease in patients with treatment-naïve early rheumatoid arthritis.

DOI: 10.1186/s13075-014-0434-z
PubMed: 25249397

Affiliations:

Le document en format XML

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<author><name sortKey="Schelde, Karen Kr Mmer" sort="Schelde, Karen Kr Mmer" uniqKey="Schelde K" first="Karen Kr Mmer" last="Schelde">Karen Kr Mmer Schelde</name>
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<author><name sortKey="Kragstrup, Tue Wenzel" sort="Kragstrup, Tue Wenzel" uniqKey="Kragstrup T" first="Tue Wenzel" last="Kragstrup">Tue Wenzel Kragstrup</name>
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<author><name sortKey="Stengaard Pedersen, Kristian" sort="Stengaard Pedersen, Kristian" uniqKey="Stengaard Pedersen K" first="Kristian" last="Stengaard-Pedersen">Kristian Stengaard-Pedersen</name>
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<author><name sortKey="Stengaard Pedersen, Kristian" sort="Stengaard Pedersen, Kristian" uniqKey="Stengaard Pedersen K" first="Kristian" last="Stengaard-Pedersen">Kristian Stengaard-Pedersen</name>
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<author><name sortKey="H Rslev Petersen, Kim" sort="H Rslev Petersen, Kim" uniqKey="H Rslev Petersen K" first="Kim" last="H Rslev-Petersen">Kim H Rslev-Petersen</name>
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<author><name sortKey="Junker, Peter" sort="Junker, Peter" uniqKey="Junker P" first="Peter" last="Junker">Peter Junker</name>
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<author><name sortKey=" Stergaard, Mikkel" sort=" Stergaard, Mikkel" uniqKey=" Stergaard M" first="Mikkel" last=" Stergaard">Mikkel  Stergaard</name>
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<series><title level="j">Arthritis research & therapy</title>
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<term>Arthritis, Rheumatoid (blood)</term>
<term>Arthritis, Rheumatoid (diagnosis)</term>
<term>Arthritis, Rheumatoid (drug therapy)</term>
<term>Chemokine CXCL13 (blood)</term>
<term>Drug Therapy, Combination</term>
<term>Early Diagnosis</term>
<term>Female</term>
<term>Humans</term>
<term>Joints (drug effects)</term>
<term>Joints (metabolism)</term>
<term>Joints (pathology)</term>
<term>Male</term>
<term>Methotrexate (therapeutic use)</term>
<term>Middle Aged</term>
<term>Predictive Value of Tests</term>
<term>Prognosis</term>
<term>Remission Induction</term>
<term>Severity of Illness Index</term>
<term>Time Factors</term>
<term>Treatment Outcome</term>
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<term>Prognosis</term>
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<front><div type="abstract" xml:lang="en">A key phenomenon in rheumatoid arthritis is the formation of lymphoid follicles in the inflamed synovial membrane. C-X-C motif chemokine 13 (CXCL13) is central in this process as it attracts C-X-C chemokine receptor type 5 (CXCR5)-expressing B cells and T follicular helper cells to the follicle. We here examine the role of CXCL13 and its association with disease in patients with treatment-naïve early rheumatoid arthritis.</div>
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<tree><noCountry><name sortKey=" Stergaard, Mikkel" sort=" Stergaard, Mikkel" uniqKey=" Stergaard M" first="Mikkel" last=" Stergaard">Mikkel  Stergaard</name>
<name sortKey="Deleuran, Bent" sort="Deleuran, Bent" uniqKey="Deleuran B" first="Bent" last="Deleuran">Bent Deleuran</name>
<name sortKey="Greisen, Stinne Ravn" sort="Greisen, Stinne Ravn" uniqKey="Greisen S" first="Stinne Ravn" last="Greisen">Stinne Ravn Greisen</name>
<name sortKey="H Rslev Petersen, Kim" sort="H Rslev Petersen, Kim" uniqKey="H Rslev Petersen K" first="Kim" last="H Rslev-Petersen">Kim H Rslev-Petersen</name>
<name sortKey="Hetland, Merete Lund" sort="Hetland, Merete Lund" uniqKey="Hetland M" first="Merete Lund" last="Hetland">Merete Lund Hetland</name>
<name sortKey="Hvid, Malene" sort="Hvid, Malene" uniqKey="Hvid M" first="Malene" last="Hvid">Malene Hvid</name>
<name sortKey="Junker, Peter" sort="Junker, Peter" uniqKey="Junker P" first="Peter" last="Junker">Peter Junker</name>
<name sortKey="Kragstrup, Tue Wenzel" sort="Kragstrup, Tue Wenzel" uniqKey="Kragstrup T" first="Tue Wenzel" last="Kragstrup">Tue Wenzel Kragstrup</name>
<name sortKey="Rasmussen, Tue Kruse" sort="Rasmussen, Tue Kruse" uniqKey="Rasmussen T" first="Tue Kruse" last="Rasmussen">Tue Kruse Rasmussen</name>
<name sortKey="Schelde, Karen Kr Mmer" sort="Schelde, Karen Kr Mmer" uniqKey="Schelde K" first="Karen Kr Mmer" last="Schelde">Karen Kr Mmer Schelde</name>
<name sortKey="Stengaard Pedersen, Kristian" sort="Stengaard Pedersen, Kristian" uniqKey="Stengaard Pedersen K" first="Kristian" last="Stengaard-Pedersen">Kristian Stengaard-Pedersen</name>
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CXCL13 predicts disease activity in early rheumatoid arthritis and could be an indicator of the therapeutic 'window of opportunity'.

CXCL13 predicts disease activity in early rheumatoid arthritis and could be an indicator of the therapeutic 'window of opportunity'.

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

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